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Researchers derived this sequence from a naturally occurring protein found in human gastric juice, where it appears to play a protective role in the digestive system

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Studies using GLP-1R and GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) knockout mice further show that loss of these receptors exaggerates allergen-induced airway inflammation, demonstrating that endogenous incretin receptor signaling normally limits type 2 innate immune responses [107]